據歐盟食品安全局消息，應歐委會的要求，歐盟食品安全局評估了胭脂樹籽皮（annatto）提取物作為食品添加劑的安全性。
胭脂樹籽皮提取物分為胭脂樹橙（bixin）基與降胭脂樹橙（norbixin）基。經過毒理學試驗，歐盟食品安全局認為，胭脂樹橙的adi設為6 mg /kg體重 /天，降胭脂樹橙的adi設為0.3 mg /kg體重/天 較為合理。
部分原文報道如下：
following a request from the european commission to efsa， the efsa panel on food additives and nutrient sources added to food （ans） was asked to re-evaluate the safety of annatto extracts， bixin-based and norbixin-based， when used as a food additive and to evaluate the safety of aqueous-processed bixin （annatto e）； solvent-extracted bixin （annatto b）； alkali-processed norbixin， acid-precipitated （annatto f）； alkali-processed norbixin， not acid-precipitated （annatto g） and solvent-extracted norbixin （annatto c） with the view to replac the currently authorised annatto extracts （e 160b）。